ШАГ 1Выберите верный вариант
ШАГ 2Добавляйте понравившиеся фразы в Избранное
What's wrong (with you)?, What's the trouble (with you)? and What's the problem? are also correct.
If the question isn't about a thing, but about some expression, we'd say: How do you say this in English?