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He's up means he's out of bed. He's upstairs (downstairs) means he's on the upper (lower) floor of the building
We say: by train, by boat, by plane, by bike; also, by land, by sea, by air, by bus; in a bus or on a bus; by car or in a car, by taxi or in a taxi; on horse-back, on a donkey, on a bicycle; on foot.
Don't use the past perfect unless there is another verb in the past tense in the same sentence.